Game crashing at first loading screen

Could you try removing your AppData? This will clear any custom options including your keybindings:

  1. Press the Windows key + R
  2. Enter %appdata% within the search input and select ‘OK’
  3. Navigate to AppData\Roaming\Fatshark
  4. Delete the entire Darktide directory

Afterwards, please launch as normal and see if there’s any improvement.