I recently started to play modded a bit and have noticed that loadouts on talents are shared between live and modded realm which is quite annoying because the balance can be quite different between them. Same for items but at least items are kind of separate since the modded loadouts are saved even if you do something in live but as soon as you change anything in modded all your items on all careers will be the ones you used in modded. It is especially troublesome when you have used a mod like give item since then when you play on live realm half your character will be having blacksmith gear for half of the slots.
So my suggestion is to make live and modded realms loadouts completely separate so that any change in equipped gear and talents on modded will not affect live and vice versa.