I just don’t understand that kind of fixed binary mindset in general. It’s a rare talent that’s so bad it’s practically never worth picking. A vast majority of talents, weapons and blessings can work depending on your build. Many don’t just work, but can be insanely powerful.
Darktide has one of the haziest, softest metas of any game I’ve played in a long while, yet so many people swear by it. 
Pretty sure their point was that it’s the winning that doesn’t work that way. Darktide just isn’t that simple.
For example, the shottie meta is probably still Full Bore & No Respite. When Scattershot & Man-Stopper has since forever been far stronger especially in crit builds.
Plasma has since the class rework been the obvious veteran meta. Yet bc of how finesse dmg buffs work, a crit / weakspot vet can push an Agri shotty far above plasma’s dmg with none of its downsides and way more ammo. Plasma is the meta not bc it’s the strongest, but because it’s ultra low effort for such high base strength.
A stamina curio on a psyker was about as off-meta as could be (maybe still is). Except psykers have atrocious base stamina but a recovery delay 2x faster than most others, and they rely heavily on mobility to survive thanks to their poor toughness/dmg resist/hp. One stamina curio for a knife psyker means 2.5x more stamina, which with the knife’s sprint effiency and that super fast recovery means virtually infinite & fast mobility, and Kinetic Deflection has a hidden property where its efficiency scales with stamina.
Zelly crusher is generally considered a weak CC option. Except it has fantastic finesse dmg, cleave, and its push attack is one of if not the best in thegame. There’s actually so much going on here that I can’t even list it or this would become too long. But the gist of it is that prior to the Invocation of Death nerf a crusher & crit & stealth zelly was likely one of the most OP zellies around. It melted everything like butter - CC:ing what it didn’t - while recharging the stealth every few seconds. It’s still really strong.
The stuff above are just examples. Things most ppl don’t even know bc they stick to the meta, thinking that’s the only thing that works. And so they never even discover the stuff that can be much stronger.
I’m not trying to insult you by calling you a meta slave here at all tho. Just saying there are so many ways to go to “win as hard as possible” that there are very few must have talents (or blessings, but that really depends on the weapon).